L-alpha-Hydroxyglutaric Acid

L-alpha-Hydroxyglutaric acid (L-2-HG) is an alpha-hydroxy acid. It is metabolized to 2-oxoglutarate (alpha-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to alpha-ketoglutarate and competitively inhibits alpha-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.Formal Name: 2S-hydroxy-pentanedioic acid. CAS Number: 13095-48-2. Synonyms: 2(S)-HG, 2(S)-Hydroxyglutaric Acid, L-2-HG, L-2-Hydroxyglutaric Acid. Molecular Formula: C5H8O5. Formula Weight: 148.1. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC(CC[C@H](O)C(O)=O)=O. InChi Code: InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m0/s1. InChi Key: HWXBTNAVRSUOJR-VKHMYHEASA-N.