KW 3902

KW 3902 is an antagonist of the adenosine A1 receptor (Ki = 0.19 nM). It displays 890-fold selectivity for A1 receptors over A2A receptors and has no activity at A3 receptors. KW 3902 less potently inhibits human organic anion transporter 1 (OAT1, Ki = 7.82 µM). KW 3902 exhibits renal protective effects during hypoxemia in rabbits.Formal Name: 8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione. CAS Number: 136199-02-5. Synonyms: MK-7418, Rolofylline. Molecular Formula: C20H28N4O2. Formula Weight: 356.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 277 nm. SMILES: O=C(N(CCC)C1=C2N=C([C@]34C[C@@H]5C[C@H]3C[C@H](C4)C5)N1)N(CCC)C2=O. InChi Code: InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)/t12-,13+,14-,20-. InChi Key: PJBFVWGQFLYWCB-OYEQCZOJSA-N.