KT195

The serine hydrolase known as alpha/beta-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (2-AG, Cay-62160) to regulate its availability at cannabinoid receptors. KT195 is a selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGLbeta. While it can be used as a probe to study ABHD6, it also has use as a negative control for studies of DAGLbeta. By inactivating ABHD6, KT195 has been shown to induce a significant accumulation of 2-AG in Neuro2a cells. KT195 is also reported to reduce IL-1beta secretion from lipopolysaccharide-treated macrophages.Formal Name: [4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone. CAS Number: 1402612-58-1. Synonyms: ML-295. Molecular Formula: C27H26N4O2. Formula Weight: 438.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml. lambdamax: 288 nm. SMILES: O=C(N1N=NC(C2=CC=C(C3=CC=C(OC)C=C3)C=C2)=C1)N4C(C5=CC=CC=C5)CCCC4. InChi Code: InChI=1S/C27H26N4O2/c1-33-24-16-14-21(15-17-24)20-10-12-22(13-11-20)25-19-31(29-28-25)27(32)30-18-6-5-9-26(30)23-7-3-2-4-8-23/h2-4,7-8,10-17,19,26H,5-6,9,18H2,1H3. InChi Key: OEHLNQDRVMDXQD-UHFFFAOYSA-N.