Kaempferol-3-glucoside

Kaempferol-3-glucoside is an orally bioavailable flavonoid that has been isolated from the leaves of D. kaki and R. agrestis and has anti-inflammatory activity. Kaempferol-3-glucoside (20-80 µg/ml) dose-dependently inhibits IL-1beta-stimulated nitric oxide and prostaglandin E2 (PGE2, Cay-14010) production in patient-derived osteoarthritis chondrocytes, an effect that is blocked by the PPAR-gamma inhibitor GW 9662 (Cay-70785). It also inhibits IL-1beta-stimulated expression of nitric oxide synthase (NOS) and COX-2 and activation of MAPK and NF-kappaB signaling. Kaempferol-3-glucoside (1-20 µM) dose-dependently prevents the loss of E-cadherin, expression of vimentin, and production of collagen type-1 in hydrogen peroxide-exposed human bronchial epithelial cells in vitro. Kaempferol-3-glucoside (1.5 mg/kg, p.o.) inhibits ear swelling and the production of IL-2 and IL-4 as well as reduces serum IgE levels in a mouse model of atopic dermatitis. Kaempferol-3-glucoside (10-20 mg/kg, p.o.) also reduces reactive oxygen species (ROS) production, collagen fiber deposition, and autophagosome formation in the epithelial lung tissue of ovalbumin-challenged mice.Formal Name: 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 480-10-4. Synonyms: Astragalin, Kaempferol 3-beta-D-glucopyranoside. Molecular Formula: C21H20O11. Formula Weight: 448.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml. lambdamax: 268, 352 nm. SMILES: O=C(C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)=C(C2=CC=C(O)C=C2)O3)C4=C3C=C(O)C=C4O. InChi Code: InChI=1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15-,17+,18-,21+/m1/s1. InChi Key: JPUKWEQWGBDDQB-QSOFNFLRSA-N.