K579

A DPP-4 inhibitor (IC50 = 5 nM for the human enzyme), reduces plasma DPP-4 activity and glucose levels and increases plasma insulin levels in an OGTT in wild-type and fa/fa Zucker fatty rats at 1 mg/kg, reduces total ulcer length in a rat model of indomethacin-induced intestinal ulcers. Formulation: A solid. InChI: InChI=1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1. InChIKey: JERPHRNGJBSFAP-AWEZNQCLSA-N. SMILES: O=C(N1CCC[C@H]1C#N)CNC2(CCN(C3=NC=CC=N3)CC2)C