(+)-JQ-1

Description: (+)-JQ-1 (JQ1) is a specific, reversible BET bromine domain inhibitor that targets BRD4 (1/2) with IC50 values of 77/33 nM. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation. Target: Autophagy, Epigenetic Reader Domain, Ligands for Target Protein for PROTAC. Smiles: CC=1C2=C(N3C([C@H](CC(OC(C)(C)C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C. References: Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23,468(7327):1067-73.