Zu "K11722" wurden 161 Artikel gefunden!
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Anti-BRD4
Artikelnummer: A301-985A100
Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...
| Schlagworte: | Anti-BRD4, Anti-HUNK1, Anti-Protein HUNK1, Anti-Bromodomain-containing protein 4 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
1.087,00 €
Anti-BRD4
Artikelnummer: A301-985A50
Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...
| Schlagworte: | Anti-BRD4, Anti-HUNK1, Anti-Protein HUNK1, Anti-Bromodomain-containing protein 4 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
621,00 €
(+)-JQ1
Artikelnummer: Cay11187-5
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. JQ1 displaces...
| Schlagworte: | (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid,... |
| Anwendung: | BRD4 inhibitor |
| CAS | 1268524-70-4 |
| MW: | 457 D |
ab 42,00 €
NEU
cis-MZ1
Artikelnummer: Cay45053-1
An inactive diastereomer of MZ1, has been used as a negative control for MZ1-induced degradation of BRD4. SMILES: CC1=NN=C2[C@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@H](O)C3)=O)=O)=O)N=C(C6=CC=C(Cl)C=C6)C7=C(SC(C)=C7C)N21. InChi Code:...
| Schlagworte: | (4S)-N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3... |
| Anwendung: | Inactive MZ1 diastereomer |
| CAS | 1797406-72-4 |
| MW: | 1002.64 D |
ab 134,00 €
Anti-BRD4 (N-Terminal Region)
Artikelnummer: NSJ-F53770-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin...
| Schlagworte: | Anti-BRD4, Anti-Protein HUNK1, Anti-Bromodomain-containing protein 4, BRD4 Antibody (N-Terminal Region) |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
361,00 €
Anti-BRD4 (C-Terminal Region)
Artikelnummer: NSJ-F53771-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin...
| Schlagworte: | Anti-BRD4, Anti-Protein HUNK1, Anti-Bromodomain-containing protein 4, BRD4 Antibody (C-Terminal Region) |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
361,00 €
Anti-BRD4 Recombinant Monoclonal
Artikelnummer: A700-005
Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...
| Schlagworte: | Anti-BRD4, Anti-HUNK1, Anti-Protein HUNK1, Anti-Bromodomain-containing protein 4 |
| Anwendung: | WB, IP, IHC, IHC-IF, ICC-IF, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 172,00 €
OXF BD 02
Artikelnummer: Cay14811-10
OXF BD 02 is an inhibitor of bromodomain 1 (BD1) in bromodomain-containing protein 4 (BRD4, IC50 = 382 nM). It is selective for BRD4 BD1 over a panel of 60 bromodomain-containing proteins but does inhibit CREB-binding protein (CBP) at 25 µM. OXF BD 02 is cytotoxic to MV4-11 acute myeloid leukemia (AML) cells (IC50 =...
| Schlagworte: | BRD4 Inhibitor Compound 8, 3-(3,5-dimethyl-4-isoxazolyl)-5-hydroxy-alpha-phenyl-benzenemethanol |
| Anwendung: | BRD4 BD1 inhibitor |
| CAS | 1429129-68-9 |
| MW: | 295.3 D |
ab 335,00 €
Anti-BRD4 Recombinant Monoclonal
Artikelnummer: A700-004
Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...
| Schlagworte: | Anti-BRD4, Anti-HUNK1, Anti-Protein HUNK1, Anti-Bromodomain-containing protein 4 |
| Anwendung: | WB, IP, IHC, ICC, ICC-IF, ChIP-Seq, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 172,00 €
MS402
Artikelnummer: Cay43481-10
A BD1-selective BET inhibitor, selectively binds to BD1 over BD2 of BRD4 (Kis = 77 and 718 nM, respectively) and, to a lesser extent, BD1 of BRD3 and BRD2 over BD2 of BRD3 and BRD2 (Kis = 110, 83, 200, and 240 nM, respectively), selective for BET BD1 over CBP, PCAF, BRG1, BPTF, and BAZ2B (Kis = 775, 4,120, 6,560,...
| Schlagworte: | 3-chloro-N-(4-methoxyphenyl)-4-[(2-methyl-3-oxo-1-cyclopenten-1-yl)amino]-benzamide |
| Anwendung: | BD1-selective BET inhibitor |
| CAS | 1672684-68-2 |
| MW: | 370.83 D |
ab 88,00 €
AZD 5153 (6-hydroxy-2-naphthoic acid)
Artikelnummer: Cay42341-10
A bivalent BRD4 inhibitor (IC50 = 5 nM) that simultaneously binds two bromodomains in BRD4, demonstrates antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma. Formulation: A solid. InChI:...
| Schlagworte: | AZD 5153 HNT salt, 6-hydroxy-2-naphthalenecarboxylic acid, compd. with... |
| Anwendung: | Bivalent BRD4 inhibitor |
| CAS | 1869912-40-2 |
| MW: | 667.8 D |
ab 201,00 €
PAG 4'-piperazine (hydrochloride)
Artikelnummer: Cay41881-100
A PROTAC building block, has been used in the synthesis of PROTACs that drive RET or BRD4 degradation. Formulation: A solid. InChI: InChI=1S/C15H20N4O2.2ClH/c20-14-6-5-13(15(21)18-14)17-11-1-3-12(4-2-11)19-9-7-16-8-10-19,,/h1-4,13,16-17H,5-10H2,(H,18,20,21),2*1H. InChIKey: RLSJIUIOQYODBF-UHFFFAOYSA-N. SMILES:...
| Schlagworte: | 3-[[4-(1-piperazinyl)phenyl]amino]-2,6-piperidinedione, dihydrochloride |
| Anwendung: | PROTAC building block |
| CAS | 2922286-32-4 |
| MW: | 361.3 D |
ab 73,00 €