JP-1302 (hydrochloride hydrate)

JP-1302 is an antagonist of alpha2-adrenergic receptors (alpha2-ARs) that is selective for alpha2C-ARs over alpha2A- and alpha2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively). It reduces immobility time in the forced swim test in mice when administered at doses of 1, 3, and 10 µmol/kg. JP-1302 (5 mg/kg) reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rats. It dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice. JP-1302 (0.3 mg/kg) also increases systolic blood pressure in rats.Formal Name: N-[4-(4-methyl-1-piperazinyl)phenyl]-9-acridinamine, dihydrochloride, hydrate. Molecular Formula: C24H24N4 . 2HCl [XH2O]. Formula Weight: 441.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Water: Soluble. SMILES: CN1CCN(C2=CC=C(NC3=C(C=CC=C4)C4=NC5=C3C=CC=C5)C=C2)CC1.Cl.Cl.O. InChi Code: InChI=1S/C24H24N4.2ClH.H2O/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24,,,/h2-13H,14-17H2,1H3,(H,25,26),2*1H,1H2. InChi Key: ABIBJNNJHQWDGO-UHFFFAOYSA-N.