JNJ-53718678

JNJ-53718678 is an inhibitor of respiratory syncytial virus (RSV) fusion. JNJ-53718678 binds to and stabilizes the RSV fusion protein in its prefusion conformation. It reduces RSV replication in RSV-infected HeLa cells (IC50 = 0.5 nM) with a 50% cytotoxic concentration (CC50) of greater than 50 µM. JNJ-53718678 (4-100 mg/kg), administered prior to infection, reduces RSV viral titers in lavaged-lung tissue and viral RNA production in the lungs in a semi-permissive cotton rat model of RSV. JNJ-53718678 also reduces RSV viral titers in bronchoalveolar lavage fluid (BALF) in a fully replicative neonatal lamb model of RSV when administered at doses of 5 and 25 mg/kg per day.Formal Name: 3-[[5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl]methyl]-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-imidazo[4,5-c]pyridin-2-one. CAS Number: 1383450-81-4. Molecular Formula: C21H20ClF3N4O3S. Formula Weight: 500.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: soluble. SMILES: O=C1N(CC2=CC3=C(N2CCCS(C)(=O)=O)C=CC(Cl)=C3)C4=C(N1CC(F)(F)F)C=CN=C4O=C1N(CC2=CC3=C(N2CCCS(C)(=O)=O)C=CC(Cl)=C3)C4=C(N1CC(F)(F)F)C=CN=C4. InChi Code: InChI=1S/C21H20ClF3N4O3S/c1-33(31,32)8-2-7-27-16(10-14-9-15(22)3-4-17(14)27)12-28-19-11-26-6-5-18(19)29(20(28)30)13-21(23,24)25/h3-6,9-11H,2,7-8,12-13H2,1H3. InChi Key: GTQTUABHRCWVLL-UHFFFAOYSA-N.