IWR-1-exo

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to beta-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response. Whereas IWR-1-endo strongly blocks cell-based Wnt/beta-catenin pathway reporter response (IC50 = 180 nM) and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 µM), IWR-1-exo has little effect in either assay at 10 µM. Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo.Formal Name: 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-benzamide. CAS Number: 1127442-87-8. Molecular Formula: C25H19N3O3. Formula Weight: 409.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 1 mg/ml, DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 0.3 mg/ml. lambdamax: 202, 241, 320 nm. SMILES: [H][C@]12[C@](C(N(C3=CC=C(C(NC4=CC=CC5=C4N=CC=C5)=O)C=C3)C2=O)=O)([H])[C@@H]6C=C[C@H]1C6. InChi Code: InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20+,21-. InChi Key: ZGSXEXBYLJIOGF-BTYSMDAFSA-N.