IWP-O1

IWP-O1 is an inhibitor of porcupine (PORCN), an enzyme that catalyzes palmitoylation of Wnt proteins. It inhibits Wnt signaling in L-Wnt-STF cells (IC50 = 80 pM in a reporter assay) and phosphorylation of Dishevelled-2 (Dvl2) and Dvl3 in HeLa cells when used at a concentration of 1 µM. IWP-O1 (1 µM) enhances the cytotoxicity of the glycolysis inhibitors 2-deoxyglucose (2-DG) and lonidamine (Cay-14640) in CAL 27 oral squamous cell carcinoma (OSCC) cells.Formal Name: 5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl)-1H-1,2,3-triazole-1-acetamide. CAS Number: 2074607-48-8. Synonyms: Inhibitor of Wnt Production-O1. Molecular Formula: C26H20N6O. Formula Weight: 432.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. lambdamax: 268 nm. SMILES: O=C(CN1N=NC(C2=CC=NC=C2)=C1C3=CC=CC=C3)NC4=CC=C(C5=CC=CC=C5)C=N4. InChi Code: InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33). InChi Key: GYYDQHBKIHQHEB-UHFFFAOYSA-N.