Zu "K00181" wurden 37 Artikel gefunden!
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LGK974
Artikelnummer: Cay14072-5
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4...
| Schlagworte: | PORCN Inhibitor IV, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide |
| Anwendung: | PORCN inhibitor |
| CAS | 1243244-14-5 |
| MW: | 396.4 D |
ab 56,00 €
IWP-2
Artikelnummer: Cay13951-1
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to beta-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production...
| Schlagworte: | Inhibitor of Wnt Production-2,... |
| Anwendung: | Porcupine inactivator |
| CAS | 686770-61-6 |
| MW: | 466.6 D |
ab 42,00 €
IWP-4
Artikelnummer: Cay13954-1
IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM. IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 µM, IWP-4 has been shown to...
| Schlagworte: | Inhibitor of Wnt Production-4,... |
| Anwendung: | Wnt production inhibitor, porcupine inactivator |
| CAS | 686772-17-8 |
| MW: | 496.6 D |
ab 57,00 €
Wnt-C59
Artikelnummer: Cay16644-1
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. Wnt-C59 is a potent inhibitor of PORCN, as measured by prevention of Wnt3A...
| Schlagworte: | PORCN Inhibitor II, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-benzeneacetamide |
| Anwendung: | Porcupine inhibitor |
| CAS | 1243243-89-1 |
| MW: | 379.5 D |
ab 42,00 €
IWP-L6
Artikelnummer: Cay15243-5
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM). It suppresses the...
| Schlagworte: | PORCN Inhibitor III, Wnt Pathway Inhibitor XIX,... |
| Anwendung: | Potent PORCN inhibitor |
| CAS | 1427782-89-5 |
| MW: | 472.6 D |
ab 123,00 €
LGK-974
Artikelnummer: LKT-L2540.1
LGK-974 inhibits PORCN, suppressing Wnt signaling. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials. LGK-974 inhibits proliferation and induces differentiation of pancreatic adenocarcinoma xenografts, it also shows efficacy in suppressing tumor growth in animal models...
| Schlagworte: | LGK974 |
| Anwendung: | PORCN inhibitor |
| CAS | 1243244-14-5 |
| MW: | 396.44 D |
ab 109,00 €
IWP-2
Artikelnummer: LKT-I9060.5
IWP-2 is an inhibitor of PORCN that inhibits Wnt signaling, exhibiting anticancer activity. IWP-2 increases activity of caspases 3 and 7, inhibiting proliferation, migration, and invasion of gastric cancer cells and colorectal cancer cells.
| Schlagworte: | IWP2 |
| Anwendung: | Porcupine inactivator |
| CAS | 686770-61-6 |
| MW: | 466.6 D |
ab 94,00 €
IWP-2-V2
Artikelnummer: Cay13952-1
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to beta-catenin activation of gene transcription. IWP-2 (Cay-13951) is an inhibitor of Wnt...
| Schlagworte: | Inhibitor of Wnt Production-2-V2,... |
| Anwendung: | Wnt/beta-catenin pathway inhibitor |
| CAS | 877618-79-6 |
| MW: | 480.6 D |
ab 57,00 €
IWP-3
Artikelnummer: Cay13953-1
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to beta-catenin activation of gene transcription. IWP-3 is an inhibitor of Wnt production...
| Schlagworte: | Inhibitor of Wnt Production-3,... |
| Anwendung: | Porcupine inactivator |
| CAS | 687561-60-0 |
| MW: | 484.6 D |
ab 57,00 €
ETC-159
Artikelnummer: Cay24104-1
ETC-159 is a potent and orally bioavailable inhibitor of porcupine (PORCN, IC50s = 18.1 and 70 nM for mouse and Xenopus PORCN, respectively). It inhibits beta-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier protein WLS via decreased Wnt palmitoleation in STF3A cells, an...
| Schlagworte: | ETC-1922159, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide |
| Anwendung: | Porcupine (PORCN) inhibitor |
| CAS | 1638250-96-0 |
| MW: | 391.4 D |
ab 49,00 €
Wnt-C59
Artikelnummer: BPS-27780-1
Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
| Schlagworte: | 2-[4-(2-Methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide, |
| Anwendung: | Wnt signaling antagonist, PORCN inhibitor |
| MW: | 379.5 D |
ab 389,00 €
Human PORCN ELISA Kit
Artikelnummer: G-HUFI01952.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €