IU1-47

IU1-47 is an inhibitor of ubiquitin-specific protease 14 (USP14, IC50 = 0.6 µM). It is selective for USP14 over USP5 (IC50 = 20 µM). IU1-47 increases degradation of a ubiquitinated proteasome substrate in a cell-free assay. It reduces tau levels in wild-type mouse embryonic fibroblasts (MEFs) expressing human tau but not Usp14-null MEFs expressing human tau. IU1-47 (25 µM) reduces tau levels in primary rat cortical neurons. It also decreases migration of, and increases autophagy in, A549 and H1299 cancer cells.Formal Name: 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)-ethanone. CAS Number: 670270-31-2. Molecular Formula: C19H23ClN2O. Formula Weight: 330.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml. lambdamax: 251 nm. SMILES: ClC1=CC=C(C=C1)N2C(C)=CC(C(CN3CCCCC3)=O)=C2C. InChi Code: InChI=1S/C19H23ClN2O/c1-14-12-18(19(23)13-21-10-4-3-5-11-21)15(2)22(14)17-8-6-16(20)7-9-17/h6-9,12H,3-5,10-11,13H2,1-2H3. InChi Key: VXQIPRWKLACSKZ-UHFFFAOYSA-N.