ITI-214 free base

Description: ITI-214 free base, a picomolar PDE1 inhibitor (Ki = 58 pM), exhibits excellent selectivity against other PDE family members and a range of enzymes, receptors, transporters, and ion channels. Target: Others. Smiles: [H][C@@]12CCC[C@]1([H])N1C(=N2)N(C)C(=O)c2c(Nc3ccccc3)n(Cc3ccc(cc3)-c3cccc(F)n3)nc12. References: Li P, et al. Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. J Med Chem. 2016 Feb 11,59(3):1149-64.