IT-901

Description: IT-901 is an orally active and potent NF-kappaB subunit c-Rel inhibitor with IC50 values for NF-kappaB and c-Rel binding to DNA of 0.1 µM and 3 µM, respectively. IT-901 is a naphthalene thiobarbiturate derivative with antitumor activity and is used for the prevention and treatment of human lymphoma and myeloma. Target: Others. Smiles: C(C=1C2=C(C(OC)=CC1OC)C=CC=C2)=C3C(=O)NC(=S)NC3=O. References: Vaisitti T, et al. Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cellsby a novel NF-kappaB inhibitor. Haematologica. 2017 Nov,102(11):1878-1889.