Isoorientin

Isoorientin is a flavonoid that has been found in G. olivieri and has diverse biological activities. It induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells in a concentration-dependent manner. Isoorientin reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-alpha in RAW 264.7 cells. In vivo, isoorientin (20 mg/kg) reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice. It increases stomach levels of superoxide dismutase (SOD) and glutathione (GSH) and reduces ulcer area in a rat model of gastric ulcers induced by indomethacin (Cay-70270).Formal Name: 2-(3,4-dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one. CAS Number: 4261-42-1. Synonyms: Homoorientin, Lespecapitioside, Lutonaretin. Molecular Formula: C21H20O11. Formula Weight: 448.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: slightly soluble. lambdamax: 213, 259, 272, 353 nm. SMILES: OC1=C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(O)=C(C(C=C(C3=CC(O)=C(O)C=C3)O4)=O)C4=C1. InChi Code: InChI=1S/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2/t14-,17-,19+,20-,21+/m1/s1. InChi Key: ODBRNZZJSYPIDI-VJXVFPJBSA-N. Origin: Plant/Lophatherum gracile.