Isoliquiritigenin

Isoliquiritigenin is a flavonoid that is found in Glycyrrhizae species and has diverse biological activities including anticancer, anti-steatotic, antioxidant, anti-inflammatory, gastroprotective, and estrogenic properties. It reduces tumor growth in an NCI-H1975 non-small cell lung cancer (NSCLC) mouse xenograft model when administered at doses of 1 and 5 mg/kg. Isoliquiritigenin (10 mg/kg per day) inhibits hepatic steatosis, as indicated by reduced hepatic fat and triglyceride accumulation, and increases in hepatic thiobarbituric acid-reactive substances (TBARS), inducible nitric oxide synthase (iNOS), and COX-2 levels in mice fed a high-fat diet. It also inhibits LPS-induced increases in IL-1beta and IL-6 levels in J774A.1 murine macrophages (IC50s = 7.2 and 7.16 µM, respectively). Isoliquiritigenin (5 and 10 mg/kg) reduces gastric acid secretion and gastric ulcer formation in pylorus-ligated rats. It is an estrogen receptor alpha (ERalpha) and ERbeta agonist (IC50s = 16 and 7.8 µM, respectively) and induces estrogen-responsive alkaline phosphatase activity in Ishikawa endometrial cancer cells (EC50 = 2.7 µM). Isoliquiritigenin is also a histamine H2 receptor and liver X receptor alpha (LXRalpha) antagonist.Formal Name: 1-(2E,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one. CAS Number: 961-29-5. Synonyms: GU 17, ILQ, ISL. Molecular Formula: C15H12O4. Formula Weight: 256.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 5 mg/ml. lambdamax: 372 nm. SMILES: OC1=CC=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(O)=C1. InChi Code: InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+. InChi Key: DXDRHHKMWQZJHT-FPYGCLRLSA-N.