Isocarboxazid

Isocarboxazid is an inhibitor of monoamine oxidase (MAO, IC50 = 4.8 µM for rat brain MAO). It induces a 4-fold increase in tryptamine action in isolated rat fundal strips at a concentration of 50 nM. In vivo, isocarboxazid potentiates tryptamine toxicity (LD50 = 8 mg/kg following subcutaneous administration of 250 mg/kg tryptamine). It inhibits 90% of MAO activity in isolated rat hearts and reduces cardiomegaly induced by isoproterenol (Cay-15592) in rats at a dose of 20 mg/kg. Oral administration of isocarboxazid (10 mg/kg) increases levels of dopamine and norepinephrine and reduces levels of the monoamine metabolites DOPAC, homovanillic acid (HVA, Cay-20877), and 5-hydroxy indole-3-acetic acid (5-HIAA, Cay-22889) by 43, 32, and 28%, respectively, in mouse brain. Formulations containing isocarboxazid have been used for the treatment of minor depression.Formal Name: 5-methyl-3-isoxazolecarboxylic acid, 2-(phenylmethyl)hydrazide. CAS Number: 59-63-2. Synonyms: NSC 169893, Ro 5-0831. Molecular Formula: C12H13N3O2. Formula Weight: 231.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble, Chloroform: Slightly Soluble. SMILES: O=C(C1=NOC(C)=C1)NNCC2=CC=CC=C2. InChi Code: InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16). InChi Key: XKFPYPQQHFEXRZ-UHFFFAOYSA-N.