Irosustat

Description: Irosustat (667-Coumate) is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity. Target: Others. Smiles: NS(=O)(=O)Oc1ccc2c3CCCCCc3c(=O)oc2c1. References: Raobaikady B,etal.Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate.J Steroid Biochem Mol Biol. 2003 Feb,84(2-3):351-8.