Irigenin

Irigenin is a polyketide synthase-derived isoflavonoid that has been found in B. chinensis rhizomes and has diverse biological activities. It inhibits the cytochrome P450 (CYP) isoform CYP1A (IC50 = 1.2 µM) and induces a 2-fold increase in NADPH quinone reductase activity in Hepa-1c1c7 cells when used at a concentration of 7.8 µM. Irigenin inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010), as well as increases in the levels of inducible nitric oxide synthase (iNOS) and COX-2, in RAW 264.7 cells. In vivo, irigenin (10 and 20 mg/kg) increases survival and reduces cardiac apoptosis, fibrosis, and levels of TNF-alpha, IL-6, IL-18, and IL-1beta in a mouse model of cardiotoxicity induced by doxorubicin (Cay-15007).Formal Name: 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one. CAS Number: 548-76-5. Molecular Formula: C18H16O8. Formula Weight: 360.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml, DMSO: 10 mg/ml. lambdamax: 268 nm. SMILES: O=C1C(C2=CC(OC)=C(OC)C(O)=C2)=COC3=CC(O)=C(C(O)=C13)OC. InChi Code: InChI=1S/C18H16O8/c1-23-13-5-8(4-10(19)17(13)24-2)9-7-26-12-6-11(20)18(25-3)16(22)14(12)15(9)21/h4-7,19-20,22H,1-3H3. InChi Key: TUGWPJJTQNLKCL-UHFFFAOYSA-N. Origin: Plant/Belamcanda chinensis.