IRE1alpha Kinase-IN-1

Artikelnummer	Größe	Manual	Lieferzeit	Preis
Cay43728-5	5 mg	-	6 - 10 Werktage*	429,00 €
Cay43728-10	10 mg	-	6 - 10 Werktage*	685,00 €
Cay43728-25	25 mg	-	6 - 10 Werktage*	1.283,00 €
Cay43728-50	50 mg	-	6 - 10 Werktage*	1.924,00 €

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IRE1alpha kinase-IN-1 is an allosteric inhibitor of inositol-requiring enzyme 1alpha (IRE1alpha,... mehr

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Produktinformationen "IRE1alpha Kinase-IN-1"

IRE1alpha kinase-IN-1 is an allosteric inhibitor of inositol-requiring enzyme 1alpha (IRE1alpha, IC50s = 160 and 80 nM for IRE1alpha kinase and ribonuclease activities, respectively). It is selective for IRE1alpha over a panel of 454 wild-type and mutant kinases at 1 µM. IRE1alpha kinase-IN-1 inhibits endoplasmic reticulum (ER) stress-induced IRE1alpha oligomerization in HEK293 cells (IC50 = 740 nM). SMILES ClC1=NN2C(C(NCC3CCN(CC3)C)=C1)=NC=C2C4=C(F)C=C5C(NC(NC6=CC=CC=C6)=N5)=C4 InChi Code InChI=1S/C26H26ClFN8/c1-35-9-7-16(8-10-35)14-29-22-13-24(27)34-36-23(15-30-25(22)36)18-11-20-21(12-19(18)28)33-26(32-20)31-17-5-3-2-4-6-17/h2-6,11-13,15-16,29H,7-10,14H2,1H3,(H2,31,32,33) InChi Key BPRAHARGXSNSSO-UHFFFAOYSA-N

Schlagworte:	Inositol-requiring Enzyme 1alpha Kinase Inhibitor 1, Inositol-requiring Enzyme 1alpha Kinase-IN-1, IRE1alpha Kinase Inhibitor 1, 6-chloro-3-[6-fluoro-2-(phenylamino)-1H-benzimidazol-5-yl]-N-[(1-methyl-4-piperidinyl)methyl]-imidazo[1,2-b]pyridazin-8-amine
Hersteller:	Cayman Chemical
Hersteller-Nr:	43728

Eigenschaften

Anwendung:	Allosteric IRE1alpha inhibitor
MW:	505 D
Formel:	C26H26ClFN8
Reinheit:	>98%
Format:	Solid

Datenbank Information

CAS :	2328097-41-0\| Passende Produkte
KEGG ID :	K08852 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	+20°C (International: -20°C)
Signalwort:	Danger
GHS-Piktogramme:
H-Sätze:	H301, H311, H331
P-Sätze:	P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P311, P312, P321, P330, P361+364, P403+233, P405, P501