Zu "K08852" wurden 84 Artikel gefunden!
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NEU
Anti-Recombinant IRE1alpha (Phospho Ser724), clone C111809
Artikelnummer: E-AN302189L.100
Protein function: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). In...
| Schlagworte: | Anti-ERN1, Anti-Ire1-alpha, Anti-Inositol-requiring protein 1, Anti-Endoplasmic reticulum-to-nucleus signaling 1,... |
| Anwendung: | WB, IHC, IF, IP, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 171,00 €
NEU
Anti-Recombinant Phospho-IRE1 (Ser724), clone C333014
Artikelnummer: E-AN303394L.100
Protein function: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). In...
| Schlagworte: | Anti-ERN1, Anti-Ire1-alpha, Anti-Inositol-requiring protein 1, Anti-Endoplasmic reticulum-to-nucleus signaling 1,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 171,00 €
NEU
Recombinant IRE1a, Active, Human
Artikelnummer: BBL-2373
Recombinant human IRE1a (amino acids 547-977), N-terminal 6xHis tag, 50.47 kDa, expressed and purified from baculovirus-infected insect cells. The enzyme has been thoroughly validated with the Transcreener ADP2 Kinase Assay Kits. For specific activity, please refer to the Certificate of Analysis for each individual...
| Schlagworte: | ERN1, Ire1-alpha, Inositol-requiring protein 1, Endoplasmic reticulum-to-nucleus signaling 1, Serine/threonine-protein... |
| Anwendung: | HTS, drug discovery, enzyme assays |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
ab 443,00 €
Human ERN1 (Endoplasmic Reticulum To Nucleus Signalling...
Artikelnummer: ELK-ELK4393MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ERN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ERN1. Next,...
| Schlagworte: | ERN1, Ire1-alpha, Inositol-requiring protein 1, Endoplasmic reticulum-to-nucleus signaling 1, Serine/threonine-protein... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
KIRA6
Artikelnummer: Cay19151-1
The IRE1 pathway is a component of the unfolded protein response that senses unfolded proteins via an ER luminal domain that becomes oligomerized during stress. It is associated with promoting cell survival through the activity of the IRE1alpha RNase, whose activity upregulates proteins that enhance ER protein...
| Schlagworte: | IRE1 Inhibitor IV, IRE1alpha Kinase Inhibiting RNase Attenuator 6,... |
| Anwendung: | ATP-competitive IRE1alpha kinase inhibiting RNase attenuator |
| CAS | 1589527-65-0 |
| MW: | 518.5 D |
ab 58,00 €
4µ8C
Artikelnummer: Cay22110-5
4µ8C is an inhibitor of inositol requiring enzyme 1 alpha (IRE1alpha), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress. 4µ8C inhibits IRE1alpha splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50...
| Schlagworte: | IRE1 Inhibitor III, 7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde |
| CAS | 14003-96-4 |
| MW: | 204.2 D |
ab 58,00 €
STF-083010
Artikelnummer: Cay17370-5
STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo. STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Cay-10522), an ER stress inducer....
| Schlagworte: | IRE1 Inhibitor I, N-[(2-hydroxy-naphthalenyl)methylene]-2-thiophenesulfonamide |
| Anwendung: | ERN1 endonuclease inhibitor |
| CAS | 307543-71-1 |
| MW: | 317.4 D |
ab 73,00 €
Toyocamycin (hydrate)
Artikelnummer: Cay17371-1
Toyocamycin is a natural adenosine analog first isolated from Streptomyces and shown in early studies to be cytotoxic to bacteria, fungi, and cancer cells and to have antiviral activities. Toyocamycin prevents IRE1alpha-induced mRNA cleavage (IC50 = 80 nM) and inhibits constitutive activation of XBP1 in multiple...
| Schlagworte: | NSC 63701, NSC 99843, 4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, hydrate |
| Anwendung: | Natural adenosine analog, IRE1alpha-induced mRNA cleavage inhibitor |
| MW: | 291.3 D |
ab 51,00 €
MKC-3946
Artikelnummer: Cay19152-1
MKC-3946 is an inhibitor of inositol-requiring enzyme 1alpha (IRE1alpha). It inhibits basal XBP1 splicing, a marker of IRE1alpha activity, in RPMI 8226 multiple myeloma cells in a concentration-dependent manner. MKC-3946 also inhibits XBP1 splicing induced by endoplasmic reticulum (ER) stress and reduces expression...
| Schlagworte: | 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-1-naphthalenecarboxaldehyde |
| Anwendung: | IRE1alpha inhibitor |
| CAS | 1093119-54-0 |
| MW: | 380.5 D |
ab 87,00 €
Anti-IRE1a
Artikelnummer: ARG55114.50
Protein function: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and...
| Schlagworte: | Anti-IRE1a, Anti-hIRE1p, Anti-Ire1-alpha, EC=2.7.11.1, EC=3.1.26.-, Anti-Endoribonuclease, Anti-Inositol-requiring protein... |
| Anwendung: | ELISA, ICC, IF, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
625,00 €
Anti-IRE1 alpha, Internal
Artikelnummer: ARG64730.100
Protein function: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and...
| Schlagworte: | Anti-IRE1a, Anti-hIRE1p, Anti-Ire1-alpha, EC=2.7.11.1, EC=3.1.26.-, Anti-Endoribonuclease, Anti-Inositol-requiring protein... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
ERN1 (IRE1), GST-tag
Artikelnummer: BPS-40306
Human endoplasmic reticulumto- nucleus signaling 1 (ERN1), also known as inositol-requiring protein 1 (IRE1), GenBank Accession No. NM_001433, a.a. 468-977 (end) MW = 87 kDa, expressed in a baculovirus-infected Sf9 insect cell expression system.
| Schlagworte: | IRE1a, hIRE1p, Ire1-alpha, Endoribonuclease, Inositol-requiring protein 1, Serine/threonine-protein kinase, Endoplasmic... |
| Anwendung: | Studying enzyme kinetics, small molecule inhibitor screening |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 87 kD |
901,00 €