IRAK Inhibitor 1

IRAK inhibitor 1 is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 35 nM). It is selective for IRAK4 over JNK1 and JNK2 at 10 µM. IRAK inhibitor 1 (1 µM) prevents increases in TNF-alpha and IL-12p40 levels in THP-1 cells infected with M. bovis.Formal Name: 6-imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine. CAS Number: 1042224-63-4. Synonyms: IRAK-IN-1. Molecular Formula: C17H19N5. Formula Weight: 293.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble with sonication. SMILES: C1(C2=CC=CC(NC3CCNCC3)=N2)=CN=C4C=CC=CN14. InChi Code: InChI=1S/C17H19N5/c1-2-11-22-15(12-19-17(22)6-1)14-4-3-5-16(21-14)20-13-7-9-18-10-8-13/h1-6,11-13,18H,7-10H2,(H,20,21). InChi Key: HUYUPQNBDBTPQQ-UHFFFAOYSA-N.