Zu "K04733" wurden 63 Artikel gefunden!
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Anti-IRAK4 / Interleukin-1 receptor-associated kinase 4
Artikelnummer: NSJ-FY12813
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. IRAK4 antibody detects Interleukin-1 receptor-associated kinase 4, a serine/threonine kinase that mediates innate immune signaling through Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Encoded by the IRAK4 gene on chromosome...
| Schlagworte: | Anti-IRAK4, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated kinase 4, IRAK4 Antibody /... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Anti-IRAK4
Artikelnummer: NSJ-F53765-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells,...
| Schlagworte: | Anti-IRAK4, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated kinase 4, IRAK4 Antibody |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
361,00 €
Edecesertib
Artikelnummer: Cay44286-1
Edecesertib is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 0. nM). It is selective for IRAK4 over a panel of 484 additional kinases at 1,000 nM. Edecesertib inhibits toll-like receptor 7 (TLR7) agonist-induced IFN-alpha production in isolated human whole blood (IC50 = 124 nM). Dietary...
| Schlagworte: | GS-5718 |
| Anwendung: | IRAK4 inhibitor |
| CAS | 2408839-73-4 |
| MW: | 435.46 D |
ab 172,00 €
KT474
Artikelnummer: Cay41053-1
KT474 is a proteolysis-targeting chimera (PROTAC) that drives the degradation of IL-1 receptor-associated kinase 4 (IRAK4). It induces the degradation of IRAK4 in primary mouse and rat splenocytes and isolated dog, monkey, and human peripheral blood mononuclear cells (PBMCs) with half-maximal degradation...
| Schlagworte: | SAR444656,... |
| Anwendung: | IRAK4 degrading PROTAC |
| CAS | 2432994-31-3 |
| MW: | 865.93 D |
ab 186,00 €
GLPG2534
Artikelnummer: Cay42048-1
Solulibility: DMSO: Sparingly Soluble: 1-10 mg/ml: Ethanol: Slightly Soluble: 0.1-1 mg/ml.
| Schlagworte: | 6-[6-[2-(2-hydroxyethoxy)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)amino]-3H-imidazo[4,5-b]pyridin-3-yl]-3-pyridinecarbonitrile |
| Anwendung: | IRAK4 inhibitor |
| CAS | 2095615-97-5 |
| MW: | 424.45 D |
ab 97,00 €
IRAK1 (360-380) (trifluoroacetate salt)
Artikelnummer: Cay42080-10
IL-1 receptor-associated kinase 1 (IRAK1) (360-380) is a peptide substrate of IRAK4. It has been used in competition assays to identify inhibitors of IRAK4.. Solulibility: DMSO: Soluble: =10 mg/ml: PBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml.
| Schlagworte: | IL-1 Receptor-associated Kinase 1, Interleukin-1 Receptor-associated Kinase 1, IRAK4 Peptide Substrate,... |
| Anwendung: | IRAK4 peptide substrate |
| MW: | 2285.59 D |
ab 88,00 €
Anti-IRAK4
Artikelnummer: NSJ-R31042
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Interleukin-1 receptor-associated kinase 4, also called REN64, is an IRAK family protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. Scott(2002) mapped the gene to chromosome 12...
| Schlagworte: | Anti-IRAK4, Anti-IRAK-4, EC=2.7.11.1, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
IRAK-1/4 Inhibitor
Artikelnummer: Cay17540-10
Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-kappaB activity, results in the development of some cancers and other diseases, making the development of IRAK...
| Schlagworte: | N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-benzamide |
| Anwendung: | IRAK1 inhibitor, IRAK4 inhibitor |
| CAS | 509093-47-4 |
| MW: | 395.4 D |
ab 49,00 €
PF-06650833
Artikelnummer: Cay28397-5
PF-06650833 is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 0.2 nM). It is selective for IRAK4 over a panel of 268 kinases at 200 nM but also inhibits IRAK1, MAP kinase-interacting serine/threonine protein kinase 2 (MNK2), leucine-rich repeat kinase 2 (LRRK2), CDC-like kinase 4 (Clk4), and casein...
| Schlagworte: | IRAK4i, 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide |
| Anwendung: | IRAK4 inhibitor |
| CAS | 1817626-54-2 |
| MW: | 361.4 D |
ab 112,00 €
Anti-IRAK4, N-terminal
Artikelnummer: ARG63779.100
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome...
| Schlagworte: | Anti-IRAK4, Anti-IRAK-4, EC=2.7.11.1, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated kinase 4 |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse |
871,00 €
IRAK4, active human recombinant protein
Artikelnummer: BPS-40064
Active human IRAK4 (GenBank Accession No. NM_001114182) (aminoacids 2-end) with N-terminal GST tag, MW= 77.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | Interleukin-1 receptor-associated kinase 4, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 77.5 kD |
536,00 €
Anti-IRAK-4
Artikelnummer: Cay13845-1
The toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor...
| Schlagworte: | Interleukin-1 Receptor-Associated Kinase 4 |
| Anwendung: | IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
467,00 €