Zu "K04733" wurden 47 Artikel gefunden!
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IRAK4 Inhibitor 28
Artikelnummer: Cay40167-1
IRAK4 inhibitor 28 is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 0.005 µM). It is selective for IRAK4 over IRAK1, CDC-like kinase 1 (Clk1), and Clk3 (IC50s = 0.023, 0.05, and >1 µM, respectively) but does inhibit Clk2, Clk4, and haspin (IC50s = 0.005, 0.008, and 0.004 µM, respectively). IRAK4...
| Schlagworte: | IRAK-IN-28, N-[trans-4-(4-morpholinyl)cyclohexyl]-5-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Anwendung: | IRAK4 inhibitor |
| CAS | 2196204-23-4 |
| MW: | 385.5 D |
ab 77,00 €
Human IRAK4 (Interleukin 1 Receptor Associated Kinase 4)...
Artikelnummer: ELK-ELK2060.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human IRAK4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human IRAK4. Next,...
| Schlagworte: | IRAK4, IRAK-4, EC=2.7.11.1, Renal carcinoma antigen NY-REN-64, Interleukin-1 receptor-associated kinase 4 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
IRAK4 Inhibitor 1
Artikelnummer: Cay37548-1
IRAK4 Inhibitor 1 (IRAK4-IN-1) is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 7 nM). It reduces TNF-alpha level increases induced by the toll-like receptor 7 (TLR7) agonist resiquimod (R-848, Cay-14806) in isolated human peripheral blood mononuclear cells (PBMCs, EC50 = 300 nM).Formal Name:...
| Schlagworte: | IRAK4-IN-1, 4-[[trans-4-(4-morpholinyl)cyclohexyl]amino]-6-quinazolinecarbonitrile |
| Anwendung: | IRAK4 inhibitor |
| CAS | 1820787-94-7 |
| MW: | 337.4 D |
ab 77,00 €
Anti-IRAK4
Artikelnummer: NSJ-R31042
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Interleukin-1 receptor-associated kinase 4, also called REN64, is an IRAK family protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. Scott(2002) mapped the gene to chromosome 12...
| Schlagworte: | Anti-IRAK4, Anti-IRAK-4, EC=2.7.11.1, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
IRAK-1/4 Inhibitor
Artikelnummer: Cay17540-10
Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-kappaB activity, results in the development of some cancers and other diseases, making the development of IRAK...
| Schlagworte: | N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-benzamide |
| Anwendung: | IRAK1 inhibitor, IRAK4 inhibitor |
| CAS | 509093-47-4 |
| MW: | 395.4 D |
ab 43,00 €
Emavusertib
Artikelnummer: Cay36845-5
Emavusertib is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 31.7 nM). It is selective for IRAK4 over FMS-related tyrosine kinase 3 (FLT3), cyclin-dependent kinase 2 (Cdk2), Aurora A kinase, glycogen synthase kinase 3beta (GSK3beta), and muscle-associated receptor tyrosine kinase (MUSK) at 1 µM....
| Schlagworte: | CA-4948,... |
| Anwendung: | IRAK4 inhibitor |
| CAS | 1801344-14-8 |
| MW: | 491.5 D |
ab 44,00 €
Anti-IRAK4
Artikelnummer: ARG54631.50
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome...
| Schlagworte: | Anti-IRAK4, Anti-IRAK-4, EC=2.7.11.1, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated kinase 4 |
| Anwendung: | WB, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
608,00 €
Anti-IRAK4, N-terminal
Artikelnummer: ARG63779.100
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome...
| Schlagworte: | Anti-IRAK4, Anti-IRAK-4, EC=2.7.11.1, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated kinase 4 |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse |
784,00 €
IRAK4, active human recombinant protein
Artikelnummer: BPS-40064
Active human IRAK4 (GenBank Accession No. NM_001114182) (aminoacids 2-end) with N-terminal GST tag, MW= 77.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | Interleukin-1 receptor-associated kinase 4, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 77.5 kD |
525,00 €
Anti-IRAK-4
Artikelnummer: Cay13845-1
The toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor...
| Schlagworte: | Interleukin-1 Receptor-Associated Kinase 4 |
| Anwendung: | IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
421,00 €
Anti-IRAK4 (IL-1 Receptor Associate Kinase 4)
Artikelnummer: 600-401-953
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome...
| Schlagworte: | Anti-IRAK4, Anti-IRAK-4, EC=2.7.11.1, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated kinase 4 |
| Anwendung: | ELISA, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
684,00 €
Anti-IRAK4
Artikelnummer: NSJ-F53765-0.4ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells,...
| Schlagworte: | Anti-IRAK4, Anti-IRAK-4, EC=2.7.11.1, Anti-Renal carcinoma antigen NY-REN-64, Anti-Interleukin-1 receptor-associated... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
702,00 €