Iproniazid

Iproniazid is an inhibitor of monoamine oxidase A (MAO-A) and MAO-B (IC50s = 6.56 and 7.54 µM, respectively). It reduces immobility in an open swimming test in rats, indicating antidepressant-like activity, when administered at a dose of 10 mg/kg. Iproniazid (300 and 400 mg/kg) induces acute hepatic necrosis in rats. Formulations containing iproniazid were previously used in the treatment of depression. SMILES: O=C(C1=CC=NC=C1)NNC(C)C. InChi Code: InChI=1S/C9H13N3O/c1-7(2)11-12-9(13)8-3-5-10-6-4-8/h3-7,11H,1-2H3,(H,12,13). InChi Key: NYMGNSNKLVNMIA-UHFFFAOYSA-N