Ingenol mebutate

Description: Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-alpha, PKC-beta, PKC-gamma, PKC-delta, and PKC-epsilon with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory and antitumor activity. Target: PKC, HIV Protease, gp120/CD4. Smiles: C\C=C(\C)C(=O)O[C@H]1C(C)=C[C@@]23[C@H](C)C[C@@H]4[C@H]([C@H](C=C(CO)[C@@H](O)[C@]12O)C3=O)C4(C)C. References: Ghoul A, et al. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. Cancer Res. 2009 May 15,69(10):4260-9.