Inflachromene

Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells. It is functional in vivo, downregulating proinflammatory functions of HMGB proteins and reducing neuronal damage. Inflachromene also ameliorates inflammatory pathogenesis in a mouse model of sepsis.Formal Name: 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione. CAS Number: 908568-01-4. Synonyms: ICM. Molecular Formula: C21H19N3O4. Formula Weight: 377.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 281 nm. SMILES: OC1=CC(OC(C)(C)C2=CCN(C(N(C3=CC=CC=C3)C4=O)=O)N4C25)=C5C=C1. InChi Code: InChI=1S/C21H19N3O4/c1-21(2)16-10-11-22-19(26)23(13-6-4-3-5-7-13)20(27)24(22)18(16)15-9-8-14(25)12-17(15)28-21/h3-10,12,18,25H,11H2,1-2H3. InChi Key: VVOXDJYPDCSQMI-UHFFFAOYSA-N.