Indisulam

Description: Indisulam (E 7070) is a carbonic anhydrase inhibitor and antitumor CDK inhibitor that targets the G1 phase of the cell cycle by depleting cyclin E, inducing p53 and p21, and inhibiting CDK2, thereby causing a blockade in the G1/S transition. Target: CDK, Carbonic Anhydrase. Smiles: NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2c(Cl)c[nH]c12. References: Ozawa Y.et al.E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo.Eur J Cancer. 2001 Nov,37(17):2275-82.