Indirubin

Indirubin is a natural product originally extracted from roots and leaves of the Indigo plant (I. tinctoria) used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 µM) and cyclin-dependent kinases 1 and 5 (IC50 = 10 µM for both isoforms).Formal Name: 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one. CAS Number: 479-41-4. Synonyms: C.I. 73200, Couroupitine B, Indigopurpurin, NSC 105327. Molecular Formula: C16H10N2O2. Formula Weight: 262.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml. lambdamax: 241, 289, 360 nm. SMILES: O=C(C1=CC=CC=C1N/2)C2=C3C(NC4=CC=CC=C4\3)=O. InChi Code: InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-. InChi Key: CRDNMYFJWFXOCH-YPKPFQOOSA-N.