Indiplon

Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner. Indiplon is selective for alpha1 subunits (EC50 = 2.6 nM) as compared with alpha2, alpha3, or alpha5 (EC50 = 24, 60, and 77 nM). Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.Formal Name: N-methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-acetamide. CAS Number: 325715-02-4. Synonyms: NBI 34060. Molecular Formula: C20H16N4O2S. Formula Weight: 376.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 14 mg/ml. lambdamax: 230, 312, 347 nm. SMILES: O=C(C1=CC=CS1)C2=C3N(N=C2)C(C4=CC=CC(N(C)C(C)=O)=C4)=CC=N3. InChi Code: InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3. InChi Key: CBIAWPMZSFFRGN-UHFFFAOYSA-N.