Incyclinide

Incyclinide is a non-antimicrobial chemically modified tetracycline (CMT) and an inhibitor of matrix metalloproteinase-13 (MMP-13), MMP-1, and MMP-8 (IC50s = 0.3, 34, and 48 µg/ml, respectively). It inhibits chick osteoclast digestion of isolated bovine bone when used at a concentration of 5 µg/ml and inhibits IL-1-induced glycosaminoglycan release from porcine articular cartilage explants at 10 µg/ml. Incyclinide (10 µM) also induces cytotoxicity of HeLa and SiHa human cervical cancer cells, as well as induces apoptosis in HeLa cells and cell cycle arrest at the G0/G1 phase in SiHa cells.Formal Name: (4aS,5aR,12aS)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide. CAS Number: 15866-90-7. Synonyms: CMT-3, COL-3, NSC 683551. Molecular Formula: C19H17NO7. Formula Weight: 371.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: OC1=C2[C@](CC3=CC=CC(O)=C3C2=O)([H])C[C@]4([H])[C@]1(C(C(C(N)=O)=C(C4)O)=O)O. InChi Code: InChI=1S/C19H17NO7/c20-18(26)14-11(22)6-9-5-8-4-7-2-1-3-10(21)12(7)15(23)13(8)16(24)19(9,27)17(14)25/h1-3,8-9,21-22,24,27H,4-6H2,(H2,20,26)/t8-,9-,19-/m0/s1. InChi Key: ZXFCRFYULUUSDW-OWXODZSWSA-N.