IN 1130

IN 1130 is an inhibitor of activin receptor-like kinase 5 (ALK5), also known as TGF-beta receptor type 1 (TGF-betaRI, IC50 = 5. nM). It is selective for ALK5 over a panel of 27 other kinases at 5 µM. IN 1130 (10 mg/kg per day) decreases renal fibrogenesis, inflammatory cell infiltration, and tubular atrophy in a mouse model of unilateral ureteral obstruction. It also reduces kidney levels of TGF-beta1, alpha-smooth muscle actin (alpha-SMA), hydroxyproline, and fibronectin in the same model. IN 1130 (5 mg/kg per day) decreases tunica plaque area, increases elastin fiber numbers, and reverses penile curvature in a rat model of Peyronie's disease induced by TGF-beta1 overexpression.. Solulibility: DMSO: Soluble: =10 mg/ml: Ethanol: Slightly soluble: 0.1-1 mg/ml.