IDE1

IDE1 is a small molecule capable of inducing definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50 = 125.5 nM in vitro) by activating the TGF-beta signaling pathway. IDE1-derived endodermal cells injected into E8.75 mouse embryos ex vivo have been shown to incorporate into the developing gut tube, contributing to its formation. Furthermore, when treated with either indolactam V (Cay-14647) or a standard regimen of the growth factor FGF-10, retinoic acid, and hedgehog inhibitors, IDE1-induced endodermal cells can form Pdx1-expressing pancreatic progenitors.Formal Name: 1-[2-[(2-carboxyphenyl)methylene]hydrazide]-heptanedioic acid. CAS Number: 1160927-48-9. Molecular Formula: C15H18N2O5. Formula Weight: 306.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 285 nm. SMILES: OC(CCCCCC(N/N=C([H])/C1=C(C(O)=O)C=CC=C1)=O)=O. InChi Code: InChI=1S/C15H18N2O5/c18-13(8-2-1-3-9-14(19)20)17-16-10-11-6-4-5-7-12(11)15(21)22/h4-7,10H,1-3,8-9H2,(H,17,18)(H,19,20)(H,21,22)/b16-10+. InChi Key: ABKJCDILEUEJSH-MHWRWJLKSA-N.