ICA

An inhibitor of KCa2.1/SK1 and KCa2.2/SK2 (IC50 = 43 and 123 nM, respectively, in HEK293 cells expressing the rat channels), prolongs atrial action potential duration and AERP and reduces burst pacing-induced atrial fibrillation in isoprenaline- or carbachol-stimulated isolated rat atrial tissue at 10 µM, active against M. tuberculosis H37Rv (MIC = 0.39 µM). SMILES: C1(C2=CC=CC=N2)=CSC(NC3=CC=CC=N3)=N1. InChi Code: InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17). InChi Key: RYCUBTFYRLAMFA-UHFFFAOYSA-N