IAXO-102

Description: IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling by inhibiting MAPK and p65 NF-kappaB phosphorylation, as well as the expression of TLR4-dependent proinflammatory proteins. It also prevents the development of experimental abdominal aortic aneurysm. Target: TLR. Smiles: CCCCCCCCCC CCCCO[C@H]1[C@H](O)[C@@H](CN)O[C@H](OC)[C@@H]1OCCCCCCCCCCCCCC. References: Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct,242(2):563-70.