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IAXO-102
Artikelnummer: TGM-T11598-100mg
Description: IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling by inhibiting MAPK and p65 NF-kappaB phosphorylation, as well as the expression of TLR4-dependent proinflammatory proteins. It also prevents the development of experimental abdominal aortic aneurysm. Target: TLR. Smiles: CCCCCCCCCC...
| CAS | 1115270-63-7 |
| MW: | 585.94 D |
ab 88,00 €
IAXO-102 (CD14/TLR4 Antagonist) (synthetic)
Artikelnummer: IAX-600-002-M001
Described to interfere with human, rat and mouse TLR4/CD14 signaling, other species not tested. Optimal working concentration depends upon the type, purity and concentration and of TLR4 ligand, carrier protein such as LPS-binding protein (LBP), soluble and membrane-bound CD14, the presence of TLR4 co-receptors (e.g....
| Schlagworte: | Methyl 6-deoxy-6-amino-2,3-di-O-tetradecyl-?-D-glucopyranoside |
| Anwendung: | CD14/TLR4 Antagonist |
| CAS | 1115270-63-7 |
| MW: | 585.94 D |
347,00 €
IAXO-102
Artikelnummer: Cay34567-10
IAXO-102 is a glycolipid and an antagonist of toll-like receptor 4 (TLR4). It inhibits lipid A-induced TLR4 activation in a cell-based assay (IC50 = 5.013 µM). IAXO-102 (10 mg/kg) reduces LPS-induced lethality in mice. It decreases angiotensin II-induced aortic expansion and rupture, as well as the incidence of...
| Schlagworte: | methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-alpha-D-glucopyranoside |
| Anwendung: | Glycolipid TLR4 antagonist |
| CAS | 1115270-63-7 |
| MW: | 585.9 D |
ab 100,00 €
