HT-2 Toxin-13C22

Description: HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human umbilical vein endothelial cells with an IC50value of 56.4 ng/ml.1It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM.3HT-2 toxin has been found in cereal grains and food products.4,5. Smiles: [H][13C@@]12O[13C@]3([H])[13CH]=[13C]([13CH3])[13C@H]([13CH2][13C@]3([13CH2]O[13C]([13CH3])=O)[13C@@]([13CH3])([13C@H](O)[13C@H]1O)[13C@]21[13CH2]O1)O[13C](=O)[13CH2][13CH]([13CH3])[13CH3] , t:5,TLB:19:18:22:2.3.10,24:22:2.3.10:20.18,THB:11:10:22:20.18,9:10:22:20.18,21:20:22:2.3.10,23:22:2.3.10:20.18, . References: Nielsen, C., Casteel, M., Didier, A., et al.Trichothecene-induced cytotoxicity on human cell linesMycotoxin Res.25(2)77-84(2009)