HQL-79

Description: HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 µM and IC50: 6 µM). It also shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS. Target: Others. Smiles: C(CN1CCC(CC1)OC(c1ccccc1)c1ccccc1)Cc1nnn[nH]1. References: Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2,281(22):15277-86. Epub 2006 Mar 17.