Homovanillic Acid

Homovanillic acid (HVA) is a dopamine metabolite. It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC, Cay-24912) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.Formal Name: 4-hydroxy-3-methoxy-benzeneacetic acid. CAS Number: 306-08-1. Synonyms: HVA, NSC 16682, Vanilacetic Acid. Molecular Formula: C9H10O4. Formula Weight: 182.2. Purity: >98%. Emission: 420 nm. Excitation: 312 nm. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml. lambdamax: 231, 282 nm. SMILES: OC(CC1=CC(OC)=C(O)C=C1)=O. InChi Code: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12). InChi Key: QRMZSPFSDQBLIX-UHFFFAOYSA-N.