Hh-Ag 1.5

Hh-Ag 1. is an agonist of smoothened (Smo) receptor. It induces nuclear glioma-associated oncogene 1 (Gli1) expression in a reporter assay using NIH3T3 cells (EC50 = 0. nM). InChI: InChI=1S/C28H26ClF2N3OS/c1-32-20-5-7-21(8-6-20)34(16-17-3-2-4-19(15-17)18-11-13-33-14-12-18)28(35)27-25(29)24-22(30)9-10-23(31)26(24)36-27/h2-4,9-15,20-21,32H,5-8,16H2,1H3/t20-,21- InChIKey: RXZDWPYJFCAZCW-MEMLXQNLSA-N SMILES: CN[C@H](CC1)CC[C@@H]1N(C(C2=C(Cl)C3=C(C(F)=CC=C3F)S2)=O)CC4=CC=CC(C5=CC=NC=C5)=C4