Hexahydrocurcumin

Hexahydrocurcumin is a natural product and an active metabolite of curcumin. It reduces prostaglandin E2 (PGE2) production stimulated by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) by 37% in human colonic epithelial cells when used at a concentration of 20 µM. Hexahydrocurcumin (3.125-25 µM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner. It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-kappaB activation when used at a concentration of 50 µM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil (Cay-14416).Formal Name: 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone. CAS Number: 36062-05-2. Molecular Formula: C21H26O6. Formula Weight: 374.4. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 279 nm. SMILES: OC1=C(OC)C=C(CCC(O)CC(CCC2=CC=C(O)C(OC)=C2)=O)C=C1. InChi Code: InChI=1S/C21H26O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,16,22,24-25H,3-4,7-8,13H2,1-2H3. InChi Key: RSAHICAPUYTWHW-UHFFFAOYSA-N. Origin: Plant/Curcuma longa.