GYKI 53655

GYKI 53655 is an allosteric AMPA receptor antagonist. It inhibits AMPA- and kainite-induced inward currents in whole-cell patch-clamp assays using primary rat hippocampal neurons (IC50s = 1.1 and 1.5 µM, respectively). GYKI 53655 decreases tonic and clonic audiogenic seizure severity in mice (ED50s = 1.3 and 2 mg/kg, respectively) and reduces mortality in a mouse model of global cerebral ischemia induced by magnesium dichloride (ED50 = 8.2 mg/kg). It inhibits seizures induced by maximal electroshock (MES) in mice (ED50 = 4.6 mg/kg) but induces motor impairment at a half-maximal toxic dose (TD50) value of 8.7 mg/kg.Formal Name: 5-(4-aminophenyl)-8,9-dihydro-N,8-dimethyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, monohydrochloride. CAS Number: 143692-48-2. Synonyms: LY300168. Molecular Formula: C19H20N4O3 . HCl. Formula Weight: 388.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: O=C(N1N=C(C2=C(CC1C)C=C3OCOC3=C2)C4=CC=C(N)C=C4)NC.Cl. InChi Code: InChI=1S/C19H20N4O3.ClH/c1-11-7-13-8-16-17(26-10-25-16)9-15(13)18(22-23(11)19(24)21-2)12-3-5-14(20)6-4-12,/h3-6,8-9,11H,7,10,20H2,1-2H3,(H,21,24),1H. InChi Key: ASLCSBBDVWPSQT-UHFFFAOYSA-N.