GSK682753A

An EBI2 inverse agonist, inhibits CREB activity in a reporter assay using HEK293 cells transiently transfected with EBI2 and Gqi4myr (IC50 = 53.6 nM), inhibits antibody-induced proliferation of B cells isolated from transgenic mice overexpressing human EBI2 from 0.001-1 µM. SMILES: O=C1OC2(CCN(CC2)C(/C=C/C3=CC=C(C=C3)Cl)=O)CN1CC4=CC(Cl)=C(C=C4)Cl. InChi Code: InChI=1S/C23H21Cl3N2O3/c24-18-5-1-16(2-6-18)4-8-21(29)27-11-9-23(10-12-27)15-28(22(30)31-23)14-17-3-7-19(25)20(26)13-17/h1-8,13H,9-12,14-15H2/b8-4+. InChi Key: RDDLWMWIRXGSJM-XBXARRHUSA-N