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GSK682753A
Artikelnummer: Cay45381-10
An EBI2 inverse agonist, inhibits CREB activity in a reporter assay using HEK293 cells transiently transfected with EBI2 and Gqi4myr (IC50 = 53.6 nM), inhibits antibody-induced proliferation of B cells isolated from transgenic mice overexpressing human EBI2 from 0.001-1 µM. SMILES:...
| Schlagworte: | 8-[(2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl]-3-[(34-,dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one |
| Anwendung: | EBI2 (GPR183) inverse agonist |
| CAS | 1334294-76-6 |
| MW: | 479.78 D |
ab 189,00 €
GSK682753A
Artikelnummer: TGM-T11498-2mg
Description: GSK682753A is a selective and highly potent inverse agonist of the Epstein-Barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. Target: Others. Smiles: Clc1ccc(\C=C\C(=O)N2CCC3(CN(Cc4ccc(Cl)c(Cl)c4)C(=O)O3)CC2)cc1. References: Benned-Jensen T, et al. Ligand modulation of the Epstein-Barr...
| CAS | 1334294-76-6 |
| MW: | 479.78 D |
89,00 €
