GSK3beta Inhibitor XIII

GSK3beta inhibitor XIII is an inhibitor of glycogen synthase kinase beta (GSK3beta, IC50 = 0.73 nM). It is selective for GSK3beta over cyclin-dependent kinase 2 (Cdk2), Cdk5, AP2-associated protein kinase 1 (AAK1), Pim-1, and PKCtheta (IC50s = 1.4, 6.4, 0.2, 0.38, and 0.36 µM, respectively) and a panel of 30 additional kinases (IC50s = >2 µM for all). In vivo, GSK3beta inhibitor XIII (30 mg/kg) reduces brain tau phosphorylation in a triple-transgenic mouse model of Alzheimer's disease.. SMILES: O=C(C1=CC=NN2C=C(C3=CC=CC=C3)N=C12)NC4=C(N5CCOC(C5)C)C=CN=C4. InChi Code: InChI=1S/C23H22N6O2/c1-16-14-28(11-12-31-16)21-8-9-24-13-19(21)27-23(30)18-7-10-25-29-15-20(26-22(18)29)17-5-3-2-4-6-17/h2-10,13,15-16H,11-12,14H2,1H3,(H,27,30). InChi Key: MENVSADYTLLXLP-UHFFFAOYSA-N