GSK3008348

Artikelnummer	Größe	Manual	Lieferzeit	Preis
Cay43471-1	1 mg	-	6 - 10 Werktage*	55,00 €
Cay43471-5	5 mg	-	6 - 10 Werktage*	243,00 €
Cay43471-10	10 mg	-	6 - 10 Werktage*	349,00 €
Cay43471-25	25 mg	-	6 - 10 Werktage*	604,00 €

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GSK3008348 is an integrin alphaVbeta6 inhibitor (Ki = 0.01 nM). It is selective for integrin... mehr

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Produktinformationen "GSK3008348"

GSK3008348 is an integrin alphaVbeta6 inhibitor (Ki = 0.01 nM). It is selective for integrin alphaVbeta6 over integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, and alphaVbeta8 (IC50s = 3.9, 50, 1,000, 126, and 16 nM, respectively, in cell adhesion assays). GSK3008348 induces internalization and degradation of integrin alphaVbeta6 and reduces the phosphorylation of SMAD2 in normal human bronchial epithelial (NHBE) cells. Intranasal administration of GSK3008348 (3 mg/kg) decreases lung collagen levels in a mouse model of lung fibrosis induced by bleomycin (Cay13877). SMILES OC(C[C@@H](C1=CC(N2N=C(C)C=C2C)=CC=C1)CN3C[C@H](CCC(N4)=CC=C5C4=NCCC5)CC3)=O InChi Code InChI=1S/C29H37N5O2/c1-20-15-21(2)34(32-20)27-7-3-5-24(16-27)25(17-28(35)36)19-33-14-12-22(18-33)8-10-26-11-9-23-6-4-13-30-29(23)31-26/h3,5,7,9,11,15-16,22,25H,4,6,8,10,12-14,17-19H2,1-2H3,(H,30,31)(H,35,36)/t22-,25-/m1/s1 InChi Key ZMXBIIQMSGOIRZ-RCZVLFRGSA-N

Schlagworte:	(betaS,3R)-beta-[3-(3,5-dimethyl-(1H-pyrazol-1-(yl)phenyl]-3-([2-(5,6,7,8-(tetrahydro-(1,8-(naphthyridin-(2-yl)ethyl]-1-pyrrolidinebutanoic acid
Hersteller:	Cayman Chemical
Hersteller-Nr:	43471

Eigenschaften

Anwendung:	Integrin alphaVbeta6 inhibitor
MW:	487.65 D
Formel:	C29H37N5O2
Reinheit:	>95%
Format:	Solid

Datenbank Information

CAS :	1629249-33-7\| Passende Produkte
KEGG ID :	K06487 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	-20°C (International: -20°C)
Signalwort:	Warning
GHS-Piktogramme:
H-Sätze:	H302, H315, H319, H335
P-Sätze:	P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501