GSK180

An inhibitor of kynurenine 3-monooxygenase (IC50 = 6.3 nM), selective for human over P. fluorescens kynurenine 3-monooxygenase (IC50 = 500 nM), increases circulating levels of kynurenine and kynurenic acid in mice at 27 mg/kg, protects against secondary acute lung injury and renal injury in a rat model of experimentally induced AP-MODS. Formulation: A solid. InChI: InChI=1S/C10H7Cl2NO4/c11-5-3-7-8(4-6(5)12)17-10(16)13(7)2-1-9(14)15/h3-4H,1-2H2,(H,14,15). InChIKey: MIGAKMWKMLYGJX-UHFFFAOYSA-N. SMILES: O=C1N(CCC(O)=O)C2=CC(Cl)=C(Cl)C=C2O1