GSK-3beta inhibitor 2

Description: GSK-3beta inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3beta (IC50 = 1.1 nM). GSK-3beta inhibitor 2 can be used in studies about Alzheimer's disease. Target: GSK-3. Smiles: COc1nc(sc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1. References: Sivaprakasam P, et al. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett. 2015 May 1,25(9):1856-63.