GPX4 24

GPX4 24 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of (1S,3R)-RSL3 (Cay-19288). It covalently binds to GPX4 in 4T1 murine mammary carcinoma cells in a concentration-dependent manner. GPX4 24 induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells (EC50 = 0.16 µM). It increases kidney and plasma malondialdehyde (MDA) levels in mice when administered at a dose of 200 mg/kg.Formal Name: methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-(methylsulfonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate. Synonyms: Glutathione Peroxidase 4 24, PHGPx 24, Phospholipid Hydroperoxide Glutathione Peroxidase 24. Molecular Formula: C22H21ClN2O5S. Formula Weight: 460.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml. lambdamax: 222 nm. SMILES: ClCC(N1[C@H](CC(C2=CC=CC=C2N3)=C3[C@@H]1C4=CC=C(C=C4)S(C)(=O)=O)C(OC)=O)=O. InChi Code: InChI=1S/C22H21ClN2O5S/c1-30-22(27)18-11-16-15-5-3-4-6-17(15)24-20(16)21(25(18)19(26)12-23)13-7-9-14(10-8-13)31(2,28)29/h3-10,18,21,24H,11-12H2,1-2H3/t18-,21+/m1/s1. InChi Key: GONRCSSWFFDKDJ-NQIIRXRSSA-N.