GPR52 Comp-43

GPR52 comp-43 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 µM). It reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111 cells, a heterozygous in vitro model of Huntington's disease, in a concentration-dependent manner. GPR52 comp-43 (3 µM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons isolated from the heterozygous HdhQ7/Q140 mouse model of Huntington's disease. It decreases striatal levels of soluble and insoluble mHTT, as well as increases the latency to fall in the rotarod test, in the homozygous HdhQ140 mouse model of Huntington's disease, when administered at a dose of 5 mg/kg.Formal Name: (2E)-5-phenyl-1-(2-thienyl)-2-penten-1-one. CAS Number: 1239987-91-7. Synonyms: GPR52-IN-43. Molecular Formula: C15H14OS. Formula Weight: 242.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 10 mg/ml. lambdamax: 270 nm. SMILES: O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2. InChi Code: InChI=1S/C15H14OS/c16-14(15-11-6-12-17-15)10-5-4-9-13-7-2-1-3-8-13/h1-3,5-8,10-12H,4,9H2/b10-5+. InChi Key: XUIAIACHIPOOHR-BJMVGYQFSA-N.